馬偕醫學院 Mackay Medical College
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馬偕醫學院 Mackay Medical College
師資陣容  
卓文隆
(Cho, Wen-Long)
職稱 教授兼教務長
(合聘師資)
主要學歷

美國密西根州立大學遺傳所博士

主要經歷
  • 馬偕醫學院 教授兼護理系主任 2011-2011
  • 馬偕醫學院 教授兼資訊中心主任 2010-2010
  • 馬偕醫學院 教授兼全人教育中心主任 2008-2009
  • 國立陽明大學熱帶醫學研究所暨學科教授兼科主任/所長 2001 至 2009
  • Adaptive Science on Taiwan (台灣調適醫學會) 編輯委員 2009-present
  • 外交部所羅門國際醫療援助 領隊 2008
  • 國科會生命科學推動中心審議委員 2002-2008
  • 中美洲五邦交國國際合作交流 陽明大學代表人 2006
  • 巴布亞紐幾內亞國際醫療援助 計畫主持人 2005 – 2008
  • 英國國家Medical Research Council (MRC) 計畫審查委員 2005 – 2006
  • 中國生理學雜誌 編輯委員 2004 – Present
  • 中國生理學雜誌 副主編 2004 – 2006
  • 國立陽明大學熱帶醫研究所及學科 所長及主任 2003 – 2007
  • 外交替代役專業訓練 熱帶疾病講座 2003 – 2005
  • 國立陽明大學研發處 副研發長 2003 ~ 2004
  • 國科會寄生蟲,醫事技術,實驗診斷學門 學門召集人 2002/1~ 2004/12
  • 考試院公務人員高等考試暨普通考試 典試委員 2002 – 2003
  • 國科會寄生蟲,醫事技術,實驗診斷學門 覆審委員 1998 – 2007
  • 國立陽明大學寄生蟲學科及研究所 主任與所長 1997 ~ 2000
  • 台灣寄生蟲學雜誌 編輯委員 1996 – 2005
  • 國立陽明大學寄生蟲學科及研究所 副教授 1994 ~ 2000
現職

馬偕醫學院 教授兼教務長 2009/8 迄今
馬偕醫學院 教授兼主任秘書 2010/8 迄今
國立陽明大學臨床醫學研究所/熱帶醫學科教授 2008/8迄今

教學專長

分子生物學、熱帶醫學、遺傳學、細菌學抗藥性

研究專長
  1. 院內感染包曼尼不動桿菌(Ab 菌)的診斷與抗藥性研究。
  2. 黴菌Cryptococcus穿過人體血腦障之機制研究
  3. 熱帶醫學分子生物學。
  4. 埃及斑蚊免疫系統的分生與生化的研究。
  5. 應用遺傳工程技術來預防蟲媒熱帶疾病的傅播。
  6. 登革熱病毐的相關研究。
  7. 巴布亞紐幾內亞(PNG)醫療外交及惡性瘧原蟲抗藥基因分子研究。
  8. 所羅門群島醫療外交。
學術期刊
  1. Wu RC, Cho WL*.  Cloning and characterization of microbial activated Aedes aegypti MEK4 (AaMEK4): influences of noncatalytic domains on enzymatic activity. Insect Molecular Biology. Vol.23-No.5:644-655. Jul. 2014. (SCI)
  2. Chen HP, Jiang JK, Lai PY, Chen CY, Chou TY, Chen YC, Chan CH, Lin SF, Yang CY, Chen CY, Lin CH, Lin JK, Ho DM, Cho WL*, Chan YJ.  Tumoral presence of human cytomegalovirus is associated with shorter disease-free survival in elderly patients with colorectal cancer and higher levels of intratumoral interleukin-17. Clinical Microbiology and Infection. Vol.20-No.7:664-671. Jul. 2014. (SCI)
  3. Liao YT, Kuo SC, Lee YT, Chen CP, Lin SW, Shen LJ, Fung CP, Cho WL*, Chen TL.  Sheltering effect and indirect pathogenesis of carbapenem-resistant Acinetobacter baumannii in polymicrobial infection. Antimicrobial Agents and Chemotherapy. Vol.58-No.7:3983-3990. May. 2014. (SCI)
  4. Lee YL, Liu CE, Cho WL, Kuo CL, Cheng WL, Huang CS, Liu CS.  Presence of cytomegalovirus DNA in leucocytes is associated with increased oxidative stress and subclinical atherosclerosis in healthy adults. Biomarkers. Vol.19-No.2:109-113. Mar. 2014. (SCI)
  5. Tseng HK, Liu CP, Ho MW, Lu PL, Lo HJ, Lin YH, Cho WL*, Chen YC.  Microbiological, epidemiological, and clinical characteristics and outcomes of patients with cryptococcosis in Taiwan, 1997-2010. PLoS One. Vol.17-No.8:6192-6201. Apr. 2013. (SCI)
  6. Tseng HK , Liu CP, Price MS, Jong AY, Chang JC, Toffaletti DL, Betancourt-Quiroz M, Frazzitta AE, Cho WL*, Perfect JR.  Identification of genes from the fungal pathogen Cryptococcus neoformans related to transmigration into the central nervous system. PLoS One. Vol.7-No.9:e4508-e4508. Sep. 2012. (SCI)
  7. Chen HP, Jiang JK, Chen CY, Chou TY, Chen YC, Chang YT, Lin SF, Chan CH, Yang CY, Lin CH, Lin JK, Cho WL*, Chan YJ.  Human cytomegalovirus preferentially infects the neoplastic epithelium of colorectal cancer: A quantitative and histological analysis. Journal of Clinical Virology. Vol.54-No.3:240-244. Jul. 2012. (SCI)
  8. Jong A, Wu CH, Gonzales-Gomez I, Kwon-Chung KJ, Chang YC, Tseng HK, Cho WL, Huang SH.  Hyaluronic acid receptor CD44 deficiency is associated with decreased Cryptococcus neoformans brain infection. Journal of Biological Chemistry. Vol.287-No.19:15298-15306. Mar. 2012. (SCI)
  9. Lee YT, Fung CP, Wang FD, Chen CP, Chen TL, Cho WL.  Outbreak of imipenem-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii complex harboring different carbapenemase gene-associated genetic structures in an intensive care unit. Journal Of Microbiology Immunology And Infection. Vol.45-No.1:43-51. Feb. 2012. (SCI)
  10. Cheng-Yi Chang, Te-Li Chen, Roy Chen-Chih Wu, Shu-Yi Hao.  Primary Toxoplasmosis in a Heart Transplant Recipient Presenting as Pneumonia and Pancreatitis.. Journal Chinese Medical Association. Vol.:-. Dec. 2011. (SCI)
  11. Lee YT, Chen TL, Lin YC, Fung CP, Cho WL..  Nosocomial nasal myiasis in an intubated patient. Journal of the Chinese Medical Association. Vol.74-No.8:369-371. Aug. 2011. (SCI)
  12. Chen TL, Chang WC, Kuo SC, Lee YT, Chen CP, Siu LK, Cho .  Contribution of a plasmid-borne blaOXA-58 gene with its hybrid promoter provided by IS1006 and an ISAba3-like element to beta-lactam resistance in acinetobacter genomic species 13TU.. Antimicrob Agents Chemother.. Vol.54:3107-3112. Jun. 2010. (SCI)
  13. Lee YT, Turton JF, Chen TL, Chen-Chih Wu R, Chang WC, Fung CP, Chen CP, Cho WL, Huang LY, Siu LK.  First Identification of blaOXA-51-like in Non-baumannii Acinetobacter spp... Journal of Chemotherapy. Vol.21:514-520. Oct. 2009. (SCI)
  14. Hung YT, Lee YT, Huang LJ, Chen TL, Yu KW, Fung CP, Cho .  Clinical characteristics of patients with Acinetobacter junii infection.. Journal of Microbiol Immunol Infect.. Vol.42:47-53. Jun. 2009. (SCI)
  15. Lee YT, Huang LY, Chiang DH, Chen CP, Chen TL, Wang FD, .  3 Differences in phenotypic and genotypic characteristics among imipenem-non-susceptible Acinetobacter isolates belonging to different genomic species in Taiwan.. Int Journal of Antimicrob Agents. Vol.34:580-584. Jun. 2009. (SCI)
  16. Lee YT, Turton JF, Chen TL, Chen-Chih Wu R, Chang WC, Fu.  Gene cassette arrays, antibiotic susceptibilities, and clinical characteristics of Acinetobacter baumannii bacteremic strains harboring class 1 integrons.. Journal of Microbiol Immunol Infect. Vol.42:210-219. Jun. 2009. (SCI)
  17. Lee YT, Turton JF, Chen TL, Chen-Chih Wu R, Chang WC, Fu.  First Identification of blaOXA-51-like in Non-baumannii Acinetobacter spp... Journal of Chemother. Vol.21:514-520. Jun. 2009. (SCI)
  18. Lee YT, Huang LY, Chen TL, Siu LK, Fung CP, Cho WL, Yu KW, Liu CY.  Gene cassette arrays, antibiotic susceptibilities, and clinical characteristics of Acinetobacter baumannii bacteremic strains harboring class 1 integrons.. Journal of Microbiology, Immunology and Infection. Vol.42-No.3:210-219. Jun. 2009. (SCI)
  19. Hung YT, Lee YT, Huang LJ, Chen TL, Yu KW, Fung CP, Cho WL, Liu CY.  Clinical characteristics of patients with Acinetobacter junii infection.. Journal of Microbiology, Immunology and Infection. Vol.42:47-53. Jan. 2009. (SCI)
  20. Lee YT, Huang LY, Chiang DH, Chen CP, Chen TL, Wang FD, Fung CP, Siu LK, Cho WL.  Differences in phenotypic and genotypic characteristics among imipenem-non-susceptible Acinetobacter isolates belonging to different genomic species in Taiwan.. International Journal of Antimicrobial Agents. Vol.34:580-584. Jan. 2009. (SCI)
  21. Dung-Hung Chiang, Chien-Chun Wang, Han-Yueh Kuo, Hsin-Pa.  Risk factors of attributable mortality for blood-stream infection of Acinetobacter baumannii with precise species identification.. Journal of Microbiology, Immunology and Infection. Vol.41:397-402. Jun. 2008. (SCI)
  22. Te-Li Chen, Leung-Kei Siu, Yi-Tzu Lee, Chien-Pei Chen, L.  Acinetobacter baylyi as a Pathogen for Opportunistic Infection.. Journal of Clinical Microbilogy. Vol.46:2938-2944. Jun. 2008. (SCI)
  23. Chien-Wei Liao, Chia-Kwung Fan§, Ting-Chang Kao, Dar-Der.  Brain injury-associated biomarkers of TGF-β1, S100B, GFAP, NF-L, tTG, AβPP, and tau were concomitantly enhanced and the UPS was impaired during acute brain injury caused by Toxocara canis in mice.. BMC Infectious Diseases. Vol.24:84-99. Jun. 2008. (SCI)
  24. Chien-Wei Liao, Wen-Long Cho,* Ting-Chang Kao, Kua-Eyre .  Blood-brain barrier impairment with enhanced SP, NK-1R, GFAP, and Claudin-5 expressions in experimental cerebral toxocariasis.. Parasite Immunology. Vol.30:525-534. Jun. 2008. (SCI)
  25. Chen HP, Lin JC, Yang SP, Lan YC, Weng WS, Tsai CH, Ho D.  The type-2 variant of human cytomegalovirus glycoprotein N (gN-2) is not the rarest in the Chinese population of Taiwan: Influence of primer design. J Virol Methods. Vol.151:161-164. Jun. 2008. (SCI)
  26. Li-Yueh Huang,  Te-Li Chen,  Po-Liang Lu,  Che-An Tsai,  Wen.  Dissemination of Multidrug-Resistant Acinetobacter baumannii Carrying Class 1 Integrons in Taiwan. Clinical Microbiology and Infection. Vol.14:1010-1019. Jun. 2008. (SCI)
  27. Te-Li Chen, Roy Chen-Chih Wu, Men-Fang Shaio, Chang-Phon.  Antimicrobial Agents and Chemotherapy. Acquisition of a Plasmid Borne blaOXA-58 Gene with an Upstream IS1008 Insertion Conferring a High Level of Carbapenem Resistance to Acinetobacter baumannii. Vol.52:2573-2580. Jun. 2008. (SCI)
  28. Han-Yueh Kuo, Dung-Hung Chiang, Chien-Chun Wang, Te-Li C.  Clinical significance of Blastocystis hominis: an experience from a medical center in northern Taiwan.. Journal of Microbiology, Immunology and Infection. Vol.41:222-226. Jun. 2008. (SCI)
  29. Dung-Hung Chiang, Chien-Chun Wang, Han-Yueh Kuo, Hsin-Pai Chen, Te-Li Chen, Fu-Der Wang, Wen-Long Cho, Cheng-Yi Liu.  Risk factors of attributable mortality for blood-stream infection of Acinetobacter baumannii with precise species identification.. Journal of Microbiology, Immunology and Infection. Vol.41:397-402. Jan. 2008. (SCI)
  30. George F. Mayhew, Lyric C. Bartholomay, Hang-Yen Kou, Th.  Construction and characterization of an expressed sequenced tag library for the mosquito vector Armigeres subalbatus. BMC Genomics. Vol.8:462-470. Jun. 2007. (SCI)
  31. Chen, T. L., Siu, L. K., Wu, R. C. C., Shaio, M. F., Hua.  Comparison of one-tube multiplex PCR and automated ribotyping for rapid identification of Acinetobacter baumannii.. Clinical Microbiology and Infection. Vol.13:801-806. Jun. 2007. (SCI)
  32. Wu, R.C.C., Shaio, M.F., and Cho, W. L..  A p38 MAP kinase regulates the expression of the Aedes aegypti defensin gene in mosquito cells. Insect Molecular Biology. Vol.16:389-399. Jun. 2007. (SCI)
  33. Chen, T. L., Chuang, C. L., Siu, L. K., Fung, C. P., and.  Genomic species identification is important to delineate the pathological characteristics of Acinetobacter in tunneled, cuffed hemodialysis catheter-related bacteremia. Nephrology Dialysis Transplantation. Vol.22:936-938. Jun. 2007. (SCI)
  34. Liu, I.H, Chung, Y.M, Chen, S.J, Cho WL*.  Necrotizing Retinitis Induced by Angiostrongylus cantonensis.. American journal of ophthalmology. Vol.141:577-579. Apr. 2006. (SCI)
  35. Bartholomay, L. C, Cho WL*, Rocheleau, T. A. Boyle, J. P., Beck, E. T., Fuchs, J. F., Liss, P., Rusch, M., Butler, K. M., Wu, R. C. C., Lin, S. P., Kou, H. Y., Tsao, I. Y., Huang, C. Y., Wu, T. T, Hsiao, K. J., Tsai, S. F., Yang, U. C..  Toward a description and transcriptomes of immune-activated hemocytes from the mosquito vectors, Aedes aegypti and Armigeres subalbatus.. Infection and Immunity. Vol.72:4114-4126. Apr. 2004. (SCI)
  36. Huang, S. J., Li, S. Y., Wu, R. C. C., Shaio, M. F., Wang, P. S., Cho WL.  An immune signaling kinase AaMEK3 from mosquitoes: cDNA cloning and characterization. Insect Molec. Biol. Vol.12:595-603. Apr. 2003. (SCI)
  37. Chiao, Y. C., Cho WL, Wang, P.S.  Inhibition of testosterone production by propylthiouracil in rat leydig cells.. Biology of Reproduction. Vol.67:416-422. Apr. 2002. (SCI)
  38. Cho WL, Raikhel, A.S.  A novel function of 20-hydroxyecdysone: translational repression of the lysosomal protease mRNA in the mosquito fat body. Insect Biochem. Molec. Biol. Vol.31:283-288. Apr. 2001. (SCI)
  39. Lo, Ming-Jae, Kau, Mei-Mei, Cho WL, Wang, P. S.  Aging effects on the secretion of corticosterone in male rats. J. Investigative Medicine. Vol.48:335-342. Apr. 2000. (SCI)
  40. Vladimir Kokoza, Abduelaziz Ahmed, Cho WL, Nijole Jasinskiene, Anthony A. James, Alexander Raikhel.  Engineering blood meal-activated systemic immunity in the mosquito vector. Proc. Natl. Acad. Sci. Vol.97:9144-9149. Apr. 2000. (SCI)
  41. Cho WL, Tsao, S. -M., Hays, A. R., Walter, R., Chen, J. -S., Snigirevskaya, E. S., Raikhel, A. S..  Mosquito cathepsin B-like protease involved in embryonic degradation of vitellin as a latent extraovarian precursor. J. Biol. Chem. Vol.274:13311-13321. Apr. 1999. (SCI)
  42. Kau, M. -M., Chen, J. -J., Wang, S. -W., Cho WL, Wang, P. S..  Age-related impairment of aldosterone secretion in zona glomerulosa cells of ovariectomized rats. J. Investigative Medicine. Vol.47:425-432. Apr. 1999. (SCI)
  43. Cho WL, Liu, S. H., Lee, C. H., Kuo, C. C., Chang, C. I., Chen, C. C..  Molecular cloning, characterization and tissue expression of phenoloxidase cDNA from mosquito Armigeres subalbatus inoculated with Dirofilaria immitis Microfilariae. Insect Molecular Biology. Vol.7:1-10. Apr. 1998. (SCI)
  44. Chiou, J. –Y., Huang, S. –J., Huang, S. –T., Cho WL.  Identification of immune-related protein kinases from mosquitoes (Aedes aegypti). J. Biomedical Science. Vol.5:120-126. Apr. 1998. (SCI)
  45. Huang, A. –M., Chang, T. –J., Cho WL, Chou, C. –K..  From mosquito to man: Identification of a novel protein kinase, HsHPK, which is highly expressed in human hepatoma tissues. J. Biomedical Science. Vol.5:135-140. Apr. 1998. (SCI)
  46. Kapittskaya, M. Z., Dittmer, N. T., Deitsch, K. W., Cho WL, Taylor, D. G., Leff, T., Raikhel, A. S..  Three isoforms of an HNF-4 transcription factor with tissue- and stage-specific expression in the adult mosquito. J. Biol. Chem. Vol.273:29801-29810. Apr. 1998. (SCI)
  47. Cho WL, Fu, T. -F., Chiou, J. -Y., Chen, C. -C..  Molecular characterization of a defensin gene from mosquito, Aedes aegypti. Insect Biochem. Molec. Biol. Vol.27:351-358. Apr. 1997. (SCI)
  48. Sappington, T. W., Kokoza, V. A., Cho WL, Raikhel, A. S..  Molecular characterization of the mosquito vitellogenin receptor reveals unexpected high homology to the Drosophila yolk protein receptor.. Proc. Natl. Acad. Sci. Vol.93:8934-8939. Apr. 1996. (SCI)
  49. Cho WL, Fu, Y. -C, Chen, C. -C., Ho, C. -M..  Cloning and characterization of cDNAs encoding the antibacterial peptide, defensin A, from mosquito , Aedes aegypti. Insect Biochem. Molec. Biol. Vol.26:395-402. Apr. 1996. (SCI)
  50. Deitsch, K. W., Dittmer, N., Kapitskaya, Chen, J. -S., Cho WL, Raikhel, A. S..  Regulation of gene expression by 20-hydroxyecdysone in the fat body of Aedes aegypti (Diptera: Culicidae). Eur. J. Entomol. Vol.92:237-244. Apr. 1995. (SCI)
  51. Cho WL, Kapitskaya, M. Z., Raikhel, A. S..  Mosquito ecdysteroid receptor: Analysis of the cDNA and expression during vitellogenesis. Insect Biochem. Molec. Biol. Vol.25:19-27. Apr. 1995. (SCI)
  52. Chen, J. -S., Cho WL, Raikhel, A. S..  Analysis of mosquito vitellogenin cDNA. J. Mol. Biol. Vol.237:641-647. Apr. 1994. (SCI)
  53. Cho WL, Deitsch, K. W., Chen, J. S., Ditmer, N. T., Raikhel, A. S..  Molecular Studies of Mosquito Vitellogenesis. Host Regulated Developmental Mechanisms In Vector Arthropods. Vol.0:48-55. Apr. 1993. (SCI)
  54. Cho WL, Raikhel, A. S..  Cloning of cDNA for mosquito lysosomal aspartic protease. J. Biol. Chem. Vol.267:21823-21829. Apr. 1992. (SCI)
  55. Cho WL, Dhadialla, T. S., Raikhel, A. S..  Purification and characterization of a lysosomal aspartic protease with cathepsin D activity from the mosquito. Insect Biochem. Vol.21:165-176. Apr. 1991. (SCI)
  56. Cho WL, Deitsch, K. W., Raikhel, A. S..  An extraovarian protein accumulated in mosquito oocytes is a carboxypeptidase activated in embryos. Proc. Natl. Acad. Sci. Vol.88:10821-10824. Apr. 1991. (SCI)
  57. Raikhel, A. S., Dhadialla, T. S., Cho WL, Hays, A. R., Koller, C. N..  Biosynthesis and endocytosis of yolk proteins in the mosquito. Molecular Insect Science. Vol.0:147-154. Apr. 1990. (SCI)
聯絡方式

wenlong_mmc@mmc.edu.tw

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